Gutera Enrofloxacin

Pharmacodynamic Enrofloxacin ni imiti yagutse ya bagiteri yica udukoko ikoreshwa cyane cyane ku nyamaswa za fluoroquinolone.Kuri e.coli, salmonella, klebsiella, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, proteus bacillus, bacteri za clayey Mr Charest, bacteri suppurative corynebacterium, zatsinze bagiteri zamaraso, staphylococcus aureus, mycoplasma, chlamydi na streptococcus ifite intege nke, ingaruka nke kuri bagiteri ya anaerobic.Ifite ingaruka nyuma ya antibacterial kuri bagiteri zoroshye.Uburyo bwa antibacterial action yiki gicuruzwa nuguhagarika ADN ya bagiteri, kubangamira kwigana, kwandukura no gusana ADN ya bagiteri, bagiteri ntishobora gukura no kubyara bisanzwe kandi igapfa.

Pharmacokinetics Umuti winjijwe vuba kandi rwose no gutera inshinge.Bioavailability yari 91.9% mu ngurube na 82% mu nka.Ikwirakwizwa cyane mu nyamaswa kandi irashobora kwinjira mu ngingo no mu mazi neza.Usibye amazi ya cerebrospinal fluid, ubunini bwibiyobyabwenge mubice hafi ya byose biruta ibyo muri plasma.Metabolism nyamukuru ya hepatike ni ugukuraho Ethyl yimpeta 7-piperazine kugirango itange ciprofloxacin, ikurikirwa na okiside hamwe na aside glucuronic ihuza.Ahanini unyuze mu mpyiko (impyiko zo mu bwoko bwa tubular secretion na glomerular filtration) zisohoka, 15% ~ 50% muburyo bwumwimerere kuva inkari.Kurandura igice cyubuzima bwo gutera inshinge ni amasaha 5.9 mu nka zinka, amasaha 1.5 ~ 4.5 mu ntama, namasaha 4,6 mu ngurube.